Customized Reagents for Drug Discovery

Customized Reagents for Use in Drug Metabolism and Development Studies

CYP450-GP provides superior quality research products for use in studies of the in vitro metabolism of new chemical entities (NCE) and other xenobiotics. Our specific inhibitory P450 antibodies are powerful tools for use in metabolic phenotyping investigations and, in fact, have properties preferable to chemical inhibitors for such studies. Our purified human P450 enzymes and other microsomal mono-oxygenase components can be employed, upon reconstitution, to substantiate the metabolic findings made with native liver microsomes, to derive kinetic parameters (KM and VMAX) underlying NCE catalysis and to reveal whether a given therapeutic elicits drug-drug interactions via P450 inhibition.

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